2016-10-20
Mint extract Mint essential oil, the killer of "immortal cancer"
Recently, a new clinical study from Belgium showed that peppermint extract menthol oil can be used as an antispasmodic agent for irritable bowel syndrome.
Irritable bowel syndrome (IBS) is currently considered as a disorder of intestinal function. Clinically, it is characterized by symptoms such as abdominal pain, abdominal distension, change of defecation habits, and abnormal stool characteristics. It often presents a chronic intermittent attack, and organic diseases are excluded after examination. In the past, it was commonly named as colon dysfunction, colon allergy, spastic colitis, mucinous colitis, etc., and in recent years, it is collectively called irritable bowel syndrome.
Irritable bowel syndrome (IBS) has a hidden onset, recurrent symptoms or chronic prolongation. The course of the disease can last for years to decades, but the general health is not affected. Mental, diet and other factors can induce recurrence or aggravation of symptoms. The prevalence of irritable bowel syndrome in China is 0.82% - 5.67%, and the majority of patients are young and middle-aged people aged 20-40 years. Although irritable bowel syndrome is not a fatal disease, it has a great impact on people's quality of life. The despair level of people suffering from irritable bowel syndrome is no less than that of cancer patients. Some patients believe that the disease makes life worse than death, and are recognized as "cancer that cannot die".
Mint is a perennial herb, which has been used for hundreds of years in Europe as a traditional medicine to help digestion. Menthol oil is extracted by distilling different parts of plants. Its main active component is menthol, which exists in the volatile oil. In vitro animal studies have demonstrated that menthol can inhibit gastrointestinal motility. According to recent clinical evidence, menthol oil is widely used as an antispasmodic for irritable bowel syndrome.
Although mint has been used for centuries, the mechanism of its effect on gastrointestinal sensory function is still unclear. At the same time, the effects of menthol oil and menthol show significant species and regional differences. In addition, it is impossible to infer the specific effect of menthol oil on gastric motor function in the mechanism study of human using the combination of several Chinese herbal extracts. Finally, the data on the effects of menthol oil on food induced compliance, nutritional tolerance, and sensitive gastric dilatation have not been published yet. As far as the mechanism of action is concerned, the gastrointestinal effects of menthol are at least partially mediated by M8 members of the transient receptor potential (TRP) ion channel superfamily. Transient receptor potential cation channels involve more and more cellular functions, including several management aspects of the digestive tract. In animal studies, TRPM8 channels were found in dorsal root ganglia, vagal afferent neurons, gastric fundus, colon and small intestine.
Animal studies found that peppermint can reduce intestinal peristalsis, which may be due to the role of transient receptor potential channels. Menthol oil, with menthol as the main component, is widely used as an antispasmodic in irritable bowel syndrome. The pain threshold of irritable bowel syndrome patients to intestinal contraction is lower than that of normal people, often manifested as hypersensitivity. When the pill enters the cecum, its straight sigmoid colon pressure increases, causing postprandial abdominal pain. In the current study, the effects of acute oral administration on intragastric pressure and gastric sensory function in healthy people were investigated. Compared with placebo, the intragastric pressure and motility index of proximal stomach after administration of menthol oil decreased significantly. The results showed that menthol oil reduced intragastric pressure, recent contractions and appetite.
To sum up, research shows that acute oral menthol oil does not affect the sensitivity of the stomach of healthy people or regulate the reflex of liquid drinks. Therefore, menthol oil, a mint extract, can be used as an antispasmodic agent for irritable bowel syndrome. After using peppermint oil, the symptoms related to a full meal were not affected. In addition, menthol oil can reduce intragastric pressure, proximal gastric contraction and appetite. Oral menthol oil provides patients with a new choice for the treatment of irritable bowel syndrome.
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